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Syntheses of Lissoclimide Analogues and the Investigation of Novel Halogen-pi Interactions & Progress Towards the Synthesis of Brasilicardin A Using a Polyene Cyclization Approach
Chapter 1 provides an overview of lissoclimide natural products and previous synthetic efforts. The isolation of lissoclimides and their anticancer properties against various cell lines are detailed. Subsequently, the mechanism of protein translation inhibition by chlorolissoclimide is discussed. Ou
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