bioRxiv / medRxiv
open access
State-Dependent 3D Enhancer Architecture Resolves a Shared Schizophrenia and Multiple Sclerosis Ketone and Lactate Sensing Logic Gate
Recent cross-disorder meta-analyses have revealed substantial pleiotropic genetic architectures shared between Schizophrenia (SCZ) and Multiple Sclerosis (MS). However, reliance on automated 1D positional mapping heuristics has historically misattributed the significant shared risk locus at 12q24.31
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