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DNA Methylation Trajectories in Aging
The goal of this observational study is to profile changes in DNA methylation of circulating CD4+ T and CD8+ T cells from healthy young to aged with diagnosis of HFpEF, a particular phenotype of HF which is highly prevalent in aging. The main question it aims to answer is: -Do DNA methylation biomarkers help us to understand the role of inflammation in HFpEF during aging? Our goal is to provide a simple large-scale panel of epigenetic-sensitive biomarkers useful in aged patients with HF in the early natural history of the disease (HFpEF).
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