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Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients

Lehmann, Manja et al.
eScholarship · Papers
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3202-clinical-sciences-for-2020
BACKGROUND: Apolipoprotein E ε4 (ApoE4) has been associated with an increased risk of Alzheimer's disease (AD), amyloid deposition and hypometabolism. ApoE4 is less prevalent in non-amnestic AD variants suggesting a direct effect on the clinical phenotype. However, the impact of ApoE4 on amyloid bur
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