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Liver-Targeted DGAT2 siRNA Ameliorates Steatosis and Fibrosis in a High-Fat Diet–Induced MASH Mouse Model
Diacylglycerol O-acyltransferase 2 (DGAT2), a key enzyme in hepatic triglyceride (TG) synthesis, is considered a promising therapeutic target for metabolic dysfunction-associated steatohepatitis (MASH). Small interfering RNAs (siRNAs) targeting conserved regions of human and mouse DGAT2 mRNA were
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