bioRxiv / medRxiv
open access
A lifespan single-cell atlas of the human developing hippocampus benchmarks familial Alzheimer's disease brain organoids.
Familial Alzheimer's disease (fAD) is an early-onset form of AD caused by autosomal-dominant variants in APP, PSEN1, or PSEN2, with PSEN1 accounting for most genetically defined cases [1]. The hippocampus is among the earliest and most severely affected brain regions in AD [2,3]. Human induced pluri
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