bioRxiv / medRxiv
open access
Hierarchical chromatin polyvalency governs robust gene regulation and organogenesis
Precise temporal control of gene expression is fundamental for embryonic development, yet the epigenetic and chromatin basis governing transcriptional timing remain poorly understood. The bivalency model, characterized by coexistence of H3K4me3 and H3K27me3, has been proposed to mark a poised state
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