Skin temperature circadian rhythms and dysautonomia in myalgic encephalomyelitis/chronic fatigue syndrome: the role of endothelin-1 in the vascular tone dysregulation

There is accumulating evidence of autonomic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); however, little is known about its association with circadian rhythms and endothelial dysfunction. This study aimed to explore the autonomic responses through an orthostatic test a