Single-Cell Proteomic Technologies: Tools in the quest for principles

[2506.18198] Single-Cell Proteomic Technologies: Tools in the quest for principles Skip to main content Search Submit Donate Log in Search arXiv Press Enter to search · Advanced search Quantitative Biology > Quantitative Methods arXiv:2506.18198 (q-bio) [Submitted on 22 Jun 2025] Title: Single-Cell Proteomic Technologies: Tools in the quest for principles Authors: Nikolai Slavov View a PDF of the paper titled Single-Cell Proteomic Technologies: Tools in the quest for principles, by Nikolai Slavov View PDF Abstract: Over the last decade, proteomic analysis of single cells by mass spectrometry transitioned from an uncertain possibility to a set of robust and rapidly advancing technologies supporting the accurate quantification of thousands of proteins. We review the major drivers of this progress, from establishing feasibility to powerful and increasingly scalable methods. We focus on the tradeoffs and synergies of different technological solutions within a coherent conceptual framework, which projects considerable room both for throughput scaling and for extending the analysis scope to functional protein measurements. We highlight the potential of these technologies to support the development of mechanistic biophysical models and help uncover new principles. Subjects: Quantitative Methods (q-bio.QM) ; Biomolecules (q-bio.BM); Molecular Networks (q-bio.MN) Cite as: arXiv:2506.18198 [q-bio.QM] (or arXiv:2506.18198v1 [q-bio.QM] for this version) https://doi.org/10.48550/arXiv.2506.18198 Focus to learn more arXiv-issued DOI via DataCite Journal reference: Annual Review Biophysics 55, 2026 Related DOI : https://doi.org/10.1146/annurev-biophys-021424-011450 Focus to learn more DOI(s) linking to related resources Submission history From: Nikolai Slavov [ view email ] [v1] Sun, 22 Jun 2025 23:12:49 UTC (2,127 KB) Full-text links: Access Paper: View a PDF of the paper titled Single-Cell Proteomic Technologies: Tools in the quest for principles, by Nikolai Slavov View PDF view license Current browse context: q-bio.QM < prev | next > new | recent | 2025-06 Change to browse by: q-bio q-bio.BM q-bio.MN References & Citations NASA ADS Google Scholar Semantic Scholar export BibTeX citation Loading... BibTeX formatted citation × loading... Data provided by: Bookmark Bibliographic Tools Bibliographic and Citation Tools Bibliographic Explorer Toggle Bibliographic Explorer ( What is the Explorer? ) Connected Papers Toggle Connected Papers ( What is Connected Papers? ) Litmaps Toggle Litmaps ( What is Litmaps? ) scite.ai Toggle scite Smart Citations ( What are Smart Citations? ) Code, Data, Media Code, Data and Media Associated with this Article alphaXiv Toggle alphaXiv ( What is alphaXiv? ) Links to Code Toggle CatalyzeX Code Finder for Papers ( What is CatalyzeX? ) DagsHub Toggle DagsHub ( What is DagsHub? ) GotitPub Toggle Gotit.pub ( What is GotitPub? ) Huggingface Toggle Hugging Face ( What is Huggingface? ) ScienceCast Toggle ScienceCast ( What is ScienceCast? ) Demos Demos Replicate Toggle Replicate ( What is Replicate? ) Spaces Toggle Hugging Face Spaces ( What is Spaces? ) Spaces Toggle TXYZ.AI ( What is TXYZ.AI? ) Related Papers Recommenders and Search Tools Link to Influence Flower Influence Flower ( What are Influence Flowers? ) Core recommender toggle CORE Recommender ( What is CORE? ) Author Venue Institution Topic About arXivLabs arXivLabs: experimental projects with community collaborators arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs . Which authors of this paper are endorsers? | Disable MathJax ( What is MathJax? ) We gratefully acknowledge support from our major funders , member institutions , , and all contributors. About · Help · Contact · Subscribe · Copyright · Privacy · Accessibility · Operational Status (opens in new tab) Major funding support from

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