HAL (France)
open access
Caractérisatiοn fοnctiοnnelle des fοrmes simple-chaîne et dοuble-chaîne de l'activateur tissulaire du plasminοgène dans la thrοmbοlyse
Les agents thrombolytiques sont utilisés pour initier la dégradation d’un thrombus. Les seuls autorisés dans l’AVC ischémique sont des variants de l’activateur tissulaire du plasminogène (tPA), une enzyme capable d’activer le plasminogène en plasmine qui clive les filaments de fibrine. Toutefois, ce
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