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Molecular Basis of SHIP1 Inositol 5-Phosphatase Autoinhibition and the Functional Significance in Neutrophil Chemotaxis

Drew, Emma
ScholarsBank · Reports · License: CC BY-NC-ND
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immunology
The SH2-domain containing inositol polyphosphate 5-phosphatase 1 (SHIP1) is an immune cell specific lipid phosphatase that regulates the duration of PI(3,4,5)P3 lipid signaling at the plasma membrane following receptor activation. SHIP1 plays an important role in immune cell processes such as polari
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