Dorsal Penile Nerve Cryoneurolysis for Lifelong PE

The goal of this clinical trial was to learn whether adding dorsal penile nerve cryoneurolysis to medication and behavioral therapy helps men with lifelong premature ejaculation. Cryoneurolysis is a treatment that uses cold to temporarily reduce nerve signals. The study also looked at the safety of this treatment. The main questions were: Does adding cryoneurolysis make the time from vaginal penetration to ejaculation longer after 3 months? Does adding cryoneurolysis improve premature ejaculation symptoms and satisfaction without worsening erectile function? What side effects occur after cryoneurolysis? Researchers compared cryoneurolysis plus medication and behavioral therapy with the same medication and behavioral therapy without cryoneurolysis. Participants: Took sertraline and tadalafil once daily for 3 months. Received education about behavioral techniques for better ejaculation control. Were randomly assigned either to receive one cryoneurolysis procedure or to receive no cryoneurolysis procedure. Used a stopwatch to record the time from vaginal penetration to ejaculation and completed questionnaires during follow-up.