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Prognostic Score Comparison in IPF and HP

Saglik Bilimleri Universitesi · 2022
ClinicalTrials.gov · Datasets · License: Public Domain · 2022
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gapidiopathic-pulmonary-fibrosis
The goal of this retrospective observational study is to evaluate and compare the prognostic value of GAP, ILD-GAP, and CPI scoring systems in patients diagnosed with interstitial lung diseases (ILDs), specifically Idiopathic Pulmonary Fibrosis (IPF), fibrotic Hypersensitivity Pneumonitis, and non-fibrotic Hypersensitivity Pneumonitis. The main questions it aims to answer are: * Can GAP, ILD-GAP, and CPI scores accurately predict prognosis in IPF, fibrotic HP, and non-fibrotic HP patients? * Are there differences in prognostic performance of these models across different ILD subtypes? Researchers will compare the prognostic utility of GAP, ILD-GAP, and CPI scores between IPF, fibrotic HP, and non-fibrotic HP groups to see if one scoring system offers superior predictive power. Participants: * Adults aged ≥18 years * Diagnosed between October 2011 and October 2021 at the University of Health Sciences Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital * 143 patients in total (IPF: 45, fibrotic HP: 26, non-fibrotic HP: 72) Participants' data will include: * Clinical and demographic characteristics * Symptom duration * Radiologic imaging findings * Pulmonary function test (PFT) results * Bronchoalveolar lavage (BAL) findings * Histopathological diagnoses Scoring systems will be calculated using standardized formulas as follows: * GAP (Gender, Age, Physiology) * ILD-GAP (modified GAP for CTD-ILDs) * CPI (Composite Physiologic Index = 91 - \[0.65 × %DLCO\] - \[0.53 × %FVC\] + \[0.34 × %FEV1\])
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