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The IKC-leptin axis functions as a molecular bridge between neurodevelopment and endocrine signaling
Kcnb1-null mice exhibit hypoleptinemia, disrupted Kcnb1-integrin-K+ channel complex (IKC) interactions with the leptin receptor (LepR) in proopiomelanocortin neurons, and broad neurodevelopmental and cognitive abnormalities. Because leptin is neurotrophic and IKC-LepR assemblies are prese
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