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Craving and personal functioning as mediators of extended-release buprenorphine efficacy: A four-way decomposition analysis from a randomised trial
Aims To investigate whether the treatment effect of extended-release buprenorphine (BUP-XR) on opioid-free days in opioid use disorder (OUD) is mediated by reductions in opioid craving and improvements in personal functioning. Design and setting Exploratory causal mediation analysis u
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