HAL (France)
open access
Dysregulated AKT signaling reprograms osteosarcoma to drive selective reliance on EP300
Cancers depend on transcriptional control to maintain the malignant cell state. EP300 and CBP are paralogous master epigenetic enzymes that control normal and malignant transcription. Using a cancer-wide integrative chemical-genetic analysis, we demonstrate enhanced dependency on EP300, compared wit
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