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Multi-cohort transcriptomics and donor-aware single-cell analyses prioritize <i>S100A8</i> within an emergency-myeloid, HLA-DR-low state in sepsis
Sepsis is heterogeneous, and transcripts that distinguish sepsis from health may lack clinical specificity. We tested whether S100A8 is reproducibly associated with sepsis and maps to a donor-aware myeloid state defined independently of S100A8. A discovery whole-blood cohort was analyzed on the log
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