Information thermodynamics of cellular ion pumps

[2506.11248] Information thermodynamics of cellular ion pumps Skip to main content Search Submit Donate Log in Search arXiv Press Enter to search · Advanced search Condensed Matter > Statistical Mechanics arXiv:2506.11248 (cond-mat) [Submitted on 12 Jun 2025 ( v1 ), last revised 16 Feb 2026 (this version, v2)] Title: Information thermodynamics of cellular ion pumps Authors: Julian D. Jiménez-Paz , Matthew P. Leighton , David A. Sivak View a PDF of the paper titled Information thermodynamics of cellular ion pumps, by Julian D. Jim\'enez-Paz and Matthew P. Leighton and David A. Sivak View PDF HTML (experimental) Abstract: The framework of bipartite stochastic thermodynamics is a powerful tool to analyze a composite system's internal thermodynamics. It has been used to study the components of different molecular machines such as ATP synthase. However, this approach has not yet been used to describe ion-transporting proteins despite their high-level functional similarity. Here we study the bipartite thermodynamics of the sodium-potassium pump in the nonequilibrium steady state. Using a physically intuitive partition between the ATP-consuming subsystem and the ion-transporting subsystem, we find considerable information flow comparable to other molecular machines, and Maxwell-demon behavior in the ATP-consuming subsystem. We vary ion concentrations and transmembrane voltage in a range including the neuronal action potential, and find that the information flow inverts during depolarization. Comments: 9 pages, 5 figures Subjects: Statistical Mechanics (cond-mat.stat-mech) ; Biological Physics (physics.bio-ph) Cite as: arXiv:2506.11248 [cond-mat.stat-mech] (or arXiv:2506.11248v2 [cond-mat.stat-mech] for this version) https://doi.org/10.48550/arXiv.2506.11248 Focus to learn more arXiv-issued DOI via DataCite Journal reference: Phys. Rev. Res. 8, 013155 (2026) Related DOI : https://doi.org/10.1103/n121-br2w Focus to learn more DOI(s) linking to related resources Submission history From: Matthew Leighton [ view email ] [v1] Thu, 12 Jun 2025 19:43:46 UTC (637 KB) [v2] Mon, 16 Feb 2026 18:08:16 UTC (640 KB) Full-text links: Access Paper: View a PDF of the paper titled Information thermodynamics of cellular ion pumps, by Julian D. Jim\'enez-Paz and Matthew P. Leighton and David A. Sivak View PDF HTML (experimental) TeX Source view license Current browse context: cond-mat.stat-mech < prev | next > new | recent | 2025-06 Change to browse by: cond-mat physics physics.bio-ph References & Citations NASA ADS Google Scholar Semantic Scholar export BibTeX citation Loading... BibTeX formatted citation × loading... Data provided by: Bookmark Bibliographic Tools Bibliographic and Citation Tools Bibliographic Explorer Toggle Bibliographic Explorer ( What is the Explorer? ) Connected Papers Toggle Connected Papers ( What is Connected Papers? ) Litmaps Toggle Litmaps ( What is Litmaps? ) scite.ai Toggle scite Smart Citations ( What are Smart Citations? ) Code, Data, Media Code, Data and Media Associated with this Article alphaXiv Toggle alphaXiv ( What is alphaXiv? ) Links to Code Toggle CatalyzeX Code Finder for Papers ( What is CatalyzeX? ) DagsHub Toggle DagsHub ( What is DagsHub? ) GotitPub Toggle Gotit.pub ( What is GotitPub? ) Huggingface Toggle Hugging Face ( What is Huggingface? ) ScienceCast Toggle ScienceCast ( What is ScienceCast? ) Demos Demos Replicate Toggle Replicate ( What is Replicate? ) Spaces Toggle Hugging Face Spaces ( What is Spaces? ) Spaces Toggle TXYZ.AI ( What is TXYZ.AI? ) Related Papers Recommenders and Search Tools Link to Influence Flower Influence Flower ( What are Influence Flowers? ) Core recommender toggle CORE Recommender ( What is CORE? ) IArxiv recommender toggle IArxiv Recommender ( What is IArxiv? ) Author Venue Institution Topic About arXivLabs arXivLabs: experimental projects with community collaborators arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs . Which authors of this paper are endorsers? | Disable MathJax ( What is MathJax? ) We gratefully acknowledge support from our major funders , member institutions , , and all contributors. About · Help · Contact · Subscribe · Copyright · Privacy · Accessibility · Operational Status (opens in new tab) Major funding support from

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