Interaction Between Hypertension and Periodontitis

Objective:The possible association between hypertension and periodontitis and the effect of hypertension on periodontal treatment were investigated by evaluating salivary and gingival crevicular fluid (GCF) interleukin (IL)-6 and C reactive protein (CRP) levels. Methods:Forty two healthy individuals without any previously diagnosed systemic disease \[10 periodontally healthy (control) and 10 periodontitis (CP)\] and subjects with hypertension \[13 periodontally healthy (HP) and 9 with periodontitis (CP + HP)\] participated in the study. GCF and saliva samples were obtained at baseline and four weeks after Phase I periodontal treatment. Biochemical parameters were analyzed using ELISA. Results:Before the periodontal treatment, significantly higher GCF IL-6 and CRP levels were detected in CP+HP and CP groups compared to HP and control groups (p\<0.01). Salivary CRP level in CP+HP group was found to be higher than the control group (p\<0.05). Statistically significant gingival and plaque index measurements (p\<0.01) might suggest a possible effect of hypertension on periodontal status. Periodontal treatment significantly improved the clinical indices, however biochemical parameters did not change after the treatment. Conclusion:the association of hypertension with periodontitis through local salivary and GCF mediators might be possible in disease process.