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TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers
cholangiocarcinomacolorectal-cancerhepatocellular-carcinomanon-small-cell-lung-cancerpancreatic-cancerrenal-cell-carcinomasarcomatriple-negative-breast-cancer
This is a phase 1/1b open label, multicenter dose escalation and dose expansion study to investigate the safety, tolerability and anti-tumor activity of TPST-1120, a small molecule selective antagonist of PPARα (peroxisome proliferator activated receptor alpha) as monotherapy and in combination with a systemic anticancer agent, nivolumab, an anti-PD1 antibody, in subjects with advanced solid tumors.
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