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A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma
advanced-hepatocellular-carcinomacarcinomahepatocellularhepatocellular-carcinoma-hccliver-cancerliver-diseasepembrolizumab
The purpose of the dose escalation part of the study is to characterize the safety and tolerability of ALN-BCAT as monotherapy and in combination with pembrolizumab; and to determine the recommended dose(s) for expansion (RDFE) of ALN-BCAT as monotherapy and in combination with pembrolizumab. The purpose of the dose expansion part of the of the study is to evaluate the antitumor activity of ALN-BCAT as monotherapy and in combination with pembrolizumab; to characterize the safety and tolerability of ALN-BCAT as monotherapy and in combination with pembrolizumab.
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