Correlation Between Alkaline Phosphatase and Vitamin D Among Female Students in The Faculty of Pharmacy at Arab International university

Correlation Between Alkaline Phosphatase and Vitamin D Among Female Students in The Faculty of Pharmacy at Arab International university | Zenodo Skip to main Communities My dashboard Log in Sign up Arab International University (AIU) Published November 27, 2024 | Version v1 Dataset Open Correlation Between Alkaline Phosphatase and Vitamin D Among Female Students in The Faculty of Pharmacy at Arab International university Authors/Creators Al-koutayni, Mohammad maher Description Vitamin D status is commonly assessed by measuring serum levels of 25-hydroxyvitamin D (25OHD), a lipid-soluble vitamin with a long half-life. It comprises vitamin D2 (from plant sources) and vitamin D3 (from animal sources). Vitamin D is critical for overall health, as it interacts with vitamin D receptors (VDRs) in various tissues and influences over 200 genes. A deficiency in vitamin D can affect numerous body systems, leading to widespread health issues. Globally, over 1 billion people, including both children and adults, suffer from vitamin D deficiency or insufficiency, which manifests in symptoms such as muscle weakness, bone pain, and fatigue, and is linked to diseases like neuropathy, cardiovascular issues, and immune dysfunctions. Alkaline phosphatase (ALP) is an enzyme involved in bone formation, and elevated serum levels often indicate increased bone turnover. Conditions such as osteomalacia, a disease caused by vitamin D deficiency, are associated with raised ALP levels. This study evaluated ALP levels in 151 healthy female students aged 20-30 and assessed the relationship between 25OHD and ALP in 42 samples. Vitamin D deficiency (<20 ng/ml) was observed in 66.66% of participants, while 14.28% had insufficiency (20-30 ng/ml) and 19.05% had normal levels. All participants had normal ALP levels (72-112 u/L), and a weak correlation was found between 25OHD and ALP (p=0.24). Using an ALP cutoff of 75 u/L, vitamin D deficiency could be predicted with 85.3% sensitivity but low specificity (37.5%). Files Correlation between ALP and Vitamin D.pdf Files (739.8 kB) Name Size Download all Correlation between ALP and Vitamin D.pdf md5:f05fa037061b5c46ddfcffe388248b33 739.8 kB Preview Download Additional details Identifiers ISSN 2789-7214 Related works Is supplement to Dataset:

2789-7214

(ISSN) Dates Accepted 2024-02-12 References References: 1. Rajab HA. The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline Phosphatase. Diagnostics (Basel). 2022 Nov 17;12(11):2828. doi: 10.3390/diagnostics12112828. PMID: 36428888; PMCID: PMC9689845. 2. Raza A, Syed JG, Muhammad Ali F, Danish Khan M, Ali Khan M, Haleem F, Naeem R. Incidence of Vitamin D Deficiency in Different Seasons in the Adult Karachi Population Presenting in the Medical Outpatient Department with Generalized Body Ache. Cureus. 2019 Jul 18;11(7):e5167. doi: 10.7759/cureus.5167. PMID: 31528517; PMCID: PMC6743659. 3. Bellastella G, Scappaticcio L, Longo M, Carotenuto R, Carbone C, Caruso P, Maio A, Paglionico VA, Vietri MT, Maiorino MI, Esposito K. New insights into vitamin D regulation: is there a role for alkaline phosphatase? J Endocrinol Invest. 2021 Sep;44(9):1891-1896. doi: 10.1007/s40618-021- 01503-w. Epub 2021 Jan 25. PMID: 33492600; PMCID: PMC8357672. 4. Gutch, Manish; Mandal, Uday Kumar1; Kumar, Sukriti2. Prediction of Rise in Alkaline Phosphatase at Different Vitamin D Levels. CHRISMED Journal of Health and Research 10(1):p 55-59, Jan–Mar 2023. | DOI: 10.4103/cjhr.cjhr_3_22 5. Nadeem Saqib MA, Rafique I, Hayder I et al. (2018) Comparison of vitamin D levels with bone density, calcium, phosphate and alkaline phosphatase – an insight from major cities of Pakistan. J Pak Med Assoc 68, 543–547. 6. Naderpoor N, Mousa A, de Courten M et al. (2018) The relationship between 25- hydroxyvitamin D concentration and liver enzymes in overweight or obese adults: cross- sectional and interventional outcomes. J Steroid Biochem 177, 193–199. 7. Srivastava T, Mehra N, Rathaur V K, Ahmad N. Correlation between Serum Alkaline Phosphatase and Vitamin D3 Levels among 1-14 Years Old Malnourished Children: A Descriptive Observational Study. CJP 2022; 8 (2) :711-716 8. Shaheen, Shehla & Noor, Shahid & Barakzai, Qamaruddin. (2012). Serum Alkaline Phosphatase Screening for Vitamin D Deficiency States. Journal of the College of Physicians and Surgeons-- Pakistan: JCPSP. 22. 424-7. 9. Alsharif Et Al. "Lack of correlation between vitamin D and alkaline phosphatase levels among Saudi population," MEDICAL SCIENCE, vol.25, no.107, pp.16-25, 2021 10. Kiran B., Prema A., Thilagavathi R., Jamuna Rani R. Serum 25- Hydroxy Vitamin D, Calcium,Phosphorus and Alkaline Phosphatase Levels In Healthy Adults Above the age of 20 Living in Potheri Village of Kancheepuram District, Tamilnadu. J App Pharm Sci, 2014; 4 (12): 030-034. 11. He X, Xu C, Lu Z-H, Fang X-Z, Tan J, Song Y. Low serum 25-hydroxyvitamin D levels are associated with liver injury markers in the US adult population. Public Health Nutrition. 12. Nasir A. M. Al-Jurayyan, Abdullah N. A. Al Jurayyan, Hanan I.O. Al Omran, Rushaid N. A. Al Jurayyan, Abdulaziz N. A. Al Jurayyan, Amir M.I. Babiker. Alkaline phosphatase (ALP) activity as a marker for vitamin D deficiency. American Journal of Research Co 139 Views 83 Downloads Show more details All versions This version Views Total views 139 139 Downloads Total downloads 83 83 Data volume Total data volume 61.4 MB 61.4 MB More info on how stats are collected.... Versions External resources Indexed in OpenAIRE Communities Keywords and subjects Keywords Vitamin D Deficiency, 25-Hydroxyvitamin D (25OHD), Alkaline Phosphatase (ALP), Bone Health, Vitamin D Receptors (Vdrs). Details DOI DOI Badge DOI 10.5281/zenodo.19758948 Markdown [](https://doi.org/10.5281/zenodo.19758948) reStructuredText .. image:: https://zenodo.org/badge/DOI/10.5281/zenodo.19758948.svg :target: https://doi.org/10.5281/zenodo.19758948 HTML <a href="https://doi.org/10.5281/zenodo.19758948"><img src="https://zenodo.org/badge/DOI/10.5281/zenodo.19758948.svg" alt="DOI"></a> Image URL https://zenodo.org/badge/DOI/10.5281/zenodo.19758948.svg Target URL https://doi.org/10.5281/zenodo.19758948 Resource type Dataset Publisher Zenodo Rights License Creative Commons Attribution 4.0 International The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited. Read more Citation Export Technical metadata Created April 25, 2026 Modified April 25, 2026 Jump up About About Policies Infrastructure Principles Projects Roadmap Contact Blog Blog Support Help FAQ Developers REST API OAI-PMH Contribute GitHub Donate Funded by Powered by CERN Data Centre & InvenioRDM Status Privacy policy Cookie policy Terms of Use This site uses cookies. Find out more on how we use cookies Accept all cookies Accept only essential cookies

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