HAL (France)
open access
Pharmacological analysis of negative allosteric modulation of the α7 nicotinic receptor by polyunsaturated free fatty acids
The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel mediating cholinergic signaling. Its implication in neurological disorders and inflammation has spurred the development of synthetic effectors, either orthosteric agonists acting on the extracellular domain, or positive
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