bioRxiv / medRxiv
open access
Convergent multidimensional neural phenotypes in human patients and schizophrenia-relevant mouse models identify reduced recurrent excitation in cortical circuits
ObjectiveNMDA-receptor hypofunction has been implicated as a core pathophysiological mechanism in schizophrenia, but conflicting evidence exists regarding the locus of the hypofunction--i.e. predominantly affecting receptors on pyramidal neurons or interneurons. To investigate the locus of NMDA-rece
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