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The human translation initiation multi-factor complex promotes methionyl-tRNA i binding to the 40S ribosomal subunit

Sokabe, Masaaki et al.
eScholarship · Papers · License: CC BY-NC
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The delivery of Met-tRNA(i) to the 40S ribosomal subunit is thought to occur by way of a ternary complex (TC) comprising eIF2, GTP and Met-tRNA(i). We have generated from purified human proteins a stable multifactor complex (MFC) comprising eIF1, eIF2, eIF3 and eIF5, similar to the MFC reported in y
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