bioRxiv / medRxiv
open access
Reduced Microtubule Polyglutamylation Perturbs Neuronal Function and Accelerates Tau-Induced Neurodegeneration
Microtubules are essential for neuronal functions and are involved in many neurodegenerative disorders. A posttranslational modification (PTM) of neuronal microtubules, polyglutamylation, was shown to control cargo transport, Tau protein binding to microtubules and to induce early-onset neurodegener
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