Population Pharmacokinetics of Antiepileptic in Pediatrics

The purpose of this study is to develop population pharmacokinetic models for antiepileptic drugs in a pediatric population. The interest of these models is multiple: * describe the pharmacokinetics of these molecules in children and explain the inter-individual variability of concentrations through covariates such as weight, age, co-treatments, genetic polymorphisms and renal function; * estimate maximum, minimum and exposure concentrations from the individual pharmacokinetic parameters for each patient; * propose adaptations of doses for certain classes of children (according to age, weight etc.) and individualize the doses.