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Oral Tranexamic Acid After Total Knee Arthroplasty

Rush University Medical Center · 2026
ClinicalTrials.gov · Datasets · License: Public Domain · 2026
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range-of-motiontotal-knee-arthroplasty
This is a prospective, double-blind, randomized controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in total knee arthroplasty (TKA). The study will assess pain, function, and range of motion (ROM) over a 2-year period, with key evaluations at 6 weeks and 90 days postoperatively. Hypothesis: Patients receiving 1.95g oral TXA for 3 or 7 days post-op will show improved pain, function, and ROM at 6 weeks and 90 days, with similar blood loss and transfusion rates as the control group.
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