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Dual purine starvation triggers an Iml1-Whi2-dependent autophagy pathway for survival in yeast
Purines, like amino acids, are fundamental nutrients and essential nucleotide components. ATP and GTP are generated via de novo purine biosynthesis or the salvage pathway. Yeast ADE2 encodes a key de novo pathway enzyme; ade2 mutants accumulate red pigment in vacuoles
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