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Associations between spatial distribution of immune cell subsets and clinical outcomes in patients with advanced melanoma treated with immune checkpoint inhibitors: results from the PUMA challenge.

Mark Schuiveling et al.
PubMed · Papers
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algorithmshumansimmune-checkpoint-inhibitorslymphocytesmelanomatreatment-outcome
Patients with advanced melanoma are treated with immune checkpoint inhibitors (ICIs), yet <50% of patients achieve a durable response while all patients are exposed to the risk of severe side effects. Tumor-infiltrating lymphocytes (TILs) in pathology images are associated with ICI outcomes, but man
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