Spiral
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PI3K is the dominant signalling pathway recruited by IRS proteins to mediate their effects on metabolism and growth
Objectives Insulin and Igf1 have pleiotropic effects on development, growth and metabolism. The activated insulin and IGF1 receptors engage insulin receptor substrate (IRS) proteins, intracellular adaptor molecules that recruit multiple downstream signalling pathways, including PI3K and GRB2-RAS-MAP
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