bioRxiv / medRxiv
open access
RosaSeed: Faster and Accurate Short Read Alignment Using a Configurable Seeding Strategy
Conventional short read DNA alignment algorithms, such as widely used BWA-MEM2, devote a substantial fraction of their execution time to seed generation. We present RosaSeed, a short read alignment algorithm, based on a configurable seeding framework, that significantly accelerates alignment while m
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