Targeting Ferroptosis in prostate cancers with SPOP and CHD1 defects | Zenodo Skip to main Communities My dashboard Log in Sign up Published April 23, 2026 | Version v1 Dataset Open Targeting Ferroptosis in prostate cancers with SPOP and CHD1 defects Authors/Creators Feiyu, Chen (Researcher) 1 Iqbal, Mahmud (Researcher) 1 Di, Zhao (Researcher) 1 Show affiliations 1.
MD Anderson Cancer Center Contributors Researcher (3): Feiyu, Chen 1 Iqbal, Mahmud 1 Di, Zhao 1 Show affiliations 1.
MD Anderson Cancer Center Description SPOP mutations and CHD1 deletion define distinct prostate cancer subtypes with differential ferroptosis susceptibility. SPOP mutations enhance, while CHD1 deletion impairs, GPX4 inhibitor efficacy through opposing regulation of the MYC–ACSL4 axis. Cholesterol-lowering agents restore ACSL4 expression, re-sensitizing SPOP/CHD1 co-deficient tumors to ferroptosis. These findings establish biomarker-driven combinatorial strategies for ferroptosis-based therapy in advanced prostate cancer. Files Files (176.1 kB) Name Size Download all CHD1 KO prostate cancer.xlsx md5:a2f63e3b452773ec3dd0bd30e545935f 71.1 kB Download SPOPmutant prostate cancer.xlsx md5:58474d51833aa5cc6d682d9fb846cdf3 105.0 kB Download 47 Views 27 Downloads Show more details All versions This version Views Total views 47 47 Downloads Total downloads 27 27 Data volume Total data volume 2.6 MB 2.6 MB More info on how stats are collected.... Versions External resources Indexed in OpenAIRE Communities Details DOI DOI Badge DOI 10.5281/zenodo.19714093 Markdown [](https://doi.org/10.5281/zenodo.19714093) reStructuredText .. image:: https://zenodo.org/badge/DOI/10.5281/zenodo.19714093.svg :target: https://doi.org/10.5281/zenodo.19714093 HTML <a href="https://doi.org/10.5281/zenodo.19714093"><img src="https://zenodo.org/badge/DOI/10.5281/zenodo.19714093.svg" alt="DOI"></a> Image URL https://zenodo.org/badge/DOI/10.5281/zenodo.19714093.svg Target URL https://doi.org/10.5281/zenodo.19714093 Resource type Dataset Publisher Zenodo Rights License Creative Commons Attribution 4.0 International The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited. Read more Citation Export Technical metadata Created April 23, 2026 Modified April 23, 2026 Jump up About About Policies Infrastructure Principles Projects Roadmap Contact Blog Blog Support Help FAQ Developers REST API OAI-PMH Contribute GitHub Donate Funded by Powered by CERN Data Centre & InvenioRDM Status Privacy policy Cookie policy Terms of Use This site uses cookies. Find out more on how we use cookies Accept all cookies Accept only essential cookies