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Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis
Genetic changes causing brain size expansion in human evolution have remained elusive. Notch signaling is essential for radial glia stem cell proliferation and is a determinant of neuronal number in the mammalian cortex. We find that three paralogs of human-specific NOTCH2NL are highly expressed in
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