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The Two-Way Role of Jagged1 in Cancer: A Focus on CRC
Highlights: What are the main findings? Jagged1 is cleaved, releasing an intracellular domain (Jag1-ICD). Jag1-ICD acquires oncogenic properties in CRC. What are the implications of the main findings? Jagged1 is a novel oncogenic driver that contributes to the multistep genetic model underlying the
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