bioRxiv / medRxiv
open access
Temporal control of mitochondrial mutagenesis reveals the fate of mtDNA mutations with age
Mutations in the mitochondrial genome (mtDNA) play a critical role in the aging process and a wide variety of age-related diseases. However, it remains unclear when the mutations that drive physiological decline arise. To answer this question, we generated a new mouse model in which mitochondrial mu
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