Structure-based design, synthesis, computational screening and biological evaluation of novel pyrrole fused pyrimidine derivatives targeting InhA enzyme

In this study, a series of 12 novel pyrrolyl chalcones and 22 pyrrole-fused pyrimidine derivatives were synthesized with good yields. Structural characterization was performed using FT-IR, NMR, and mass spectrometry techniques. The antitubercular potential of these compounds was evaluated using the