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PARG inhibition suppresses osteoclast differentiation through transcriptional activation of an NRF2-dependent pathway
Poly (ADP-ribose) glycohydrolase (PARG) is the main enzyme responsible for degrading poly (ADP-ribose) (PAR), which is synthesized by PARP family proteins during the poly ADP-ribosylation cycle. We previously reported that the PARG inhibitor PDD00017273 suppressed osteoclast differentiation through
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