bioRxiv / medRxiv
open access
Dual control of plasmid copy number in E. coli by combining temperature shifts and RNAI-based genetic circuits for tunable replication dynamics
Plasmid copy number (PCN) is a central determinant of recombinant gene expression levels and metabolic burden in bacterial cell factories. However, dynamic real-time control of PCN during microbial cultivation remains largely unexplored. In the ColE1/pUC19 replication system, PCN is governed by an a
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