bioRxiv / medRxiv
open access
A Mechanistic Model for the HPA Axis Cortisol Paradox in PTSD
Post-traumatic Stress Disorder (PTSD) is a debilitating psychiatric condition characterized by intrusive memories, hyperarousal, avoidance, and cognitive and mood disturbances. A longstanding biological paradox in PTSD is the observation of low basal cortisol levels, despite the expectation of eleva
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