bioRxiv / medRxiv
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Genome-Wide Association Study of Sepsis Susceptibility in ICU Patients Identifies Arab Founder Loss-of-Function Variant in UBE2L3
Sepsis causes approximately 11 million deaths globally each year. Whole-genome sequencing (WGS) of founder populations offers a unique opportunity for discovery of genes related to susceptibility of sepsis. We performed GWAS and EXWAS on WGS data for n=210 Arab ICU patients (n=68 sepsis cases, n=142
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