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Molecular Dynamics Investigation of Human Endosulfatase HSulf‑2 Reveals the Structural Roles of Intrinsically Disordered Regions, Catalytic Residues, and N‑Glycosylation

Jianjun Tao (23618136) et al. · figshare
Figshare · Datasets · License: CC BY-NC 4.0
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biochemistrybiophysicscancercomputational-biologymolecular-biology
Human endosulfatases HSulf-1 and HSulf-2 are the only extracellular sulfatases that selectively remove 6-O-sulfate groups from heparan sulfate chains, thereby regulating numerous signaling pathways involved in development, tissue homeostasis, and cancer. In particular, HSulf-2 is frequently overexpr
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