Natural Hepatoprotective Agents: A Systematic Review of Plant-Based Therapies | Zenodo Skip to main Communities My dashboard Log in Sign up INTERNATIONAL JOURNAL OF PHARMACY AND BIOLOGICAL SCIENCE (IJPBS) Published April 1, 2026 | Version v1 Journal article Open Natural Hepatoprotective Agents: A Systematic Review of Plant-Based Therapies Authors/Creators Moni Rawat * (Contact person) 1 Show affiliations 1.
Career Point School of Pharmacy, Career Point University, Kota- 325003, Rajasthan, India. Contributors Researcher: Ankit Kumar Sokiya and Moni Rawat * 1 Show affiliations 1.
Career Point School of Pharmacy, Career Point University, Kota- 325003, Rajasthan, India. Description Abstract Liver diseases remain a major global health burden, driven by factors such as alcohol consumption, viral infections, drug-induced toxicity, and metabolic disorders. Conventional pharmacological treatments are often limited by adverse effects, high costs, and variable efficacy, prompting growing interest in plant-based alternatives. This systematic review aims to evaluate the hepatoprotective potential of medicinal plants and their bioactive constituents, with a focus on mechanisms of action, preclinical and clinical evidence, and therapeutic relevance. A comprehensive literature search was conducted across major scientific databases, including PubMed, Scopus, and Web of Science, selecting studies that investigated plant-derived extracts or compounds with demonstrated liver-protective activity. such as Silybum marianum, Curcuma longa, Phyllanthus niruri, and Andrographis paniculata, exhibit significant hepatoprotective effects. These effects are primarily mediated through antioxidant, anti-inflammatory, anti-fibrotic, and detoxification pathways, including modulation of oxidative stress markers, cytokine production, and hepatic enzyme activity. Additionally, certain phytochemicals, such as flavonoids, terpenoids, and polyphenols, play a crucial role in liver regeneration and cellular protection. Despite promising preclinical data, clinical validation remains limited and heterogeneous. plant-based therapies represent a valuable and promising approach for hepatoprotection, offering potential complementary or alternative strategies in the management of liver disorders. Keywords Antioxidant, Cirrhosis, Hepatoprotection, Liver function, Metabolic disorders Files 35-41-Natural-Amit Kumar Sokiya-3-2063724734.pdf Files (602.7 kB) Name Size Download all 35-41-Natural-Amit Kumar Sokiya-3-2063724734.pdf md5:f7f727ee7e2ea1646869cf3247d9d27c 602.7 kB Preview Download Additional details References [1] Patel J, Roy H, Chintamaneni PK, Patel R, Bohara R. Advanced Strategies in Enhancing the Hepatoprotective Efficacy of Natural Products: Integrating Nanotechnology, Genomics, and Mechanistic Insights. ACS Biomater Sci Eng.11(5):2528-2549.( 2025) [2] Jaffar HM, Al-Asmari F, Khan FA, Rahim MA, Zongo E. 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(2019). 52 Views 22 Downloads Show more details All versions This version Views Total views 52 52 Downloads Total downloads 22 22 Data volume Total data volume 13.9 MB 13.9 MB More info on how stats are collected.... Versions External resources Indexed in OpenAIRE Communities Details DOI DOI Badge DOI 10.5281/zenodo.19880995 Markdown [](https://doi.org/10.5281/zenodo.19880995) reStructuredText .. image:: https://zenodo.org/badge/DOI/10.5281/zenodo.19880995.svg :target: https://doi.org/10.5281/zenodo.19880995 HTML <a href="https://doi.org/10.5281/zenodo.19880995"><img src="https://zenodo.org/badge/DOI/10.5281/zenodo.19880995.svg" alt="DOI"></a> Image URL https://zenodo.org/badge/DOI/10.5281/zenodo.19880995.svg Target URL https://doi.org/10.5281/zenodo.19880995 Resource type Journal article Publisher IJPBS-JP RESEARCH PUBLICATIONS Published in International Journal of Pharmacy and Biological Sciences (IJPBS), 16(2), 35-41, ISSN: 2230-7605, 2026. 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