HAL (France)
open access
Caractérisation structurale des interactions phospho-dépendantes entre Mdm2 et p53 entières.
La E3 ubiquitine ligase Mdm2 est le principal régulateur négatif du suppresseur de tumeur p53. L'axe de régulation Mdm2-p53 est altéré dans la quasi-totalité des cancers, ce qui en fait une cible thérapeutique majeur. Des inhibiteurs empêchant la liaison de p53 à Mdm2 ont été testés en clinique, mai
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