G-protein coupled estrogen receptor 1 (GPER1) expression improves survival of glioblastoma patients depending on sex and age: biological mechanisms and epigenetic regulation

Introduction In 2021, WHO classification of brain tumors adopted an integrated approach, combining histopathological features with key molecular alterations, notably redefining astrocytoma and glioblastoma entities. Among gliomas, glioblastoma has the worst prognosis, with a median patient survival