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Cultured Red Blood Cells : Life Span in Vivo Study

Etablissement Français du Sang · 2010
ClinicalTrials.gov · Datasets · License: Public Domain · 2010
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healthy-volunteersna
To study the in vivo life span in healthy volunteers of red blood cells generated in vitro from autologous peripheral stem cells. The study will be carried out in 4 phases : * production in vitro of the equivalent of 1 ml of blood, i.e. 5x10e9 enucleated RBC from mononuclear cells isolated from an HSC graft obtained from a healthy volunteers donor. * labeling of these cRBC with 51 Cr * reinjection of the autologous cRBC * follow up of the receivers for a maximum 33 days to measure the half-life span of the injected cells.
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