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Bistability, Absolute Concentration Robustness, and Hysteresis in Dual-Site Futile Cycles with Bifunctional Enzymes
Bifunctional enzymes, which catalyze both the forward and reverse steps of a substrate modification reaction, arise naturally in bacterial two-component signaling systems and metabolic regulation. Beyond their well-known role in conferring absolute concentration robustness (ACR) on substrate species
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