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Catalytic Atroposelective Aza-Friedel–Crafts Reactions of 2‑Arylindoles with Pyrazolinone Ketimines: Simultaneous Construction of Axial and Central Chirality
biochemistrybiophysicsbiotechnologycell-biologydevelopmental-biologyimmunologymolecular-biologysociology
A CPA-catalyzed atroposelective aza-Friedel–Crafts addition of 2-arylindoles to pyrazolinone ketimines is reported, delivering two separable diastereomeric axially chiral 2-arylindoles bearing a central chirality in high yields with excellent enantioselectivities. Single-crystal X-ray diffraction an
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