HAL (France)
open access
Controlling for DNA dosage with whole-genome sequencing improves ATAC-seq peak calling
ATAC-seq is a powerful method for mapping chromatin accessibility and identifying cis-regulatory elements (CREs) across cell types. We reveal that ATAC-seq peak calling is compromised by local biases in DNA dosage, arising from copy number variations but also from DNA replication timing. As part of
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