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Loss of cohesin deacetylation through KDAC8 inactivation leads to altered cohesin complex expression and chromosomal instability
The cohesin complex is critical for both proper gene expression and for pairing sister chromatids during mitosis to ensure proper chromosome segregation. Acetylation and deacetylation of SMC3, a component of cohesin, is a critical regulatory mechanism controlling stability and reformation of the co
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